GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11150589 | 1 | rs12598978 | chr16:30482540 | LOC595101 | chr16:30278914-30346695:- | 0.16 | 4.07 | 5.12E-5 | Ulcerative colitis;Inflammatory bowel disease |
| BRCA | cis | rs11662586 | 1 | rs12605316 | chr18:77693600 | PQLC1 | chr18:77662420-77711653:- | -0.09 | -3.44 | 0.000605 | Exploratory eye movement dysfunction in schizophrenia (responsive search score) |
| BRCA | cis | rs2287838 | 1 | rs12609594 | chr19:9972417 | OLFM2 | chr19:9964395-10047070:- | -0.18 | -6.22 | 7.13E-10 | Sleep duration |
| BRCA | cis | rs12608504 | 1 | rs12610373 | chr19:18398284 | JUND | chr19:18390563-18392432:- | -0.11 | -3.55 | 0.000395 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs12608504 | 1 | rs12610373 | chr19:18398284 | KIAA1683 | chr19:18367906-18385319:- | -0.15 | -4.59 | 4.98E-6 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs12611088 | 1 | rs12611088 | chr19:44072802 | ZNF575 | chr19:44029649-44040282:+ | -0.12 | -3.49 | 0.000509 | Plasma amyloid beta peptide concentrations (ABx-42) |
| BRCA | cis | rs10205487 | 1 | rs12613947 | chr2:70161342 | ANXA4 | chr2:69969127-70053594:+ | -0.13 | -3.83 | 0.000135 | Carotid plaque burden (smoking interaction) |
| BRCA | cis | rs11125529 | 1 | rs12615749 | chr2:54475885 | C2orf73 | chr2:54558071-54588714:+ | 0.14 | 3.5 | 0.000477 | Telomere length |
| BRCA | cis | rs13393800 | 1 | rs12617363 | chr2:233440296 | EIF4E2 | chr2:233415357-233448349:+ | -0.19 | -4.22 | 2.66E-5 | Height |
| BRCA | cis | rs13393800 | 1 | rs12617363 | chr2:233440296 | TIGD1 | chr2:233412779-233415226:- | -0.15 | -3.67 | 0.000256 | Height |
| BRCA | cis | rs2241437 | 1 | rs12617717 | chr2:86342303 | LOC90784 | chr2:86247339-86250991:- | -0.33 | -4.1 | 4.47E-5 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| BRCA | cis | rs2241437 | 1 | rs12617717 | chr2:86342303 | ST3GAL5 | chr2:86066271-86116157:- | 0.31 | 4.18 | 3.22E-5 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| BRCA | cis | rs5743030 | 1 | rs12618262 | chr2:190708073 | ORMDL1 | chr2:190634994-190649097:- | -0.23 | -3.68 | 0.000248 | Subcutaneous adipose tissue |
| BRCA | cis | rs12618769 | 1 | rs12618769 | chr2:99239931 | UNC50 | chr2:99225042-99234975:+ | 0.2 | 4.26 | 2.23E-5 | Bipolar disorder |
| BRCA | cis | rs2277912 | 1 | rs12620432 | chr2:207636518 | MDH1B | chr2:207598943-207630050:- | -0.21 | -4.7 | 2.98E-6 | Height |